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M94A2620.TXT
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1994-10-25
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Document 2620
DOCN M94A2620
TI Usefulness of indirect enzyme immunoassay for diagnosis of chlamydial
infections in infants.
DT 9412
AU Yamazaki T; Nozomu S; Honda A; Nakada H; Saitama Medical School, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):262 (abstract no. PB0477). Unique
Identifier : AIDSLINE ICA10/94369955
AB Chlamydia trachomatis (C. trachomatis) is transmitted from mothers to
children and causes conjunctivities and respiratory infections among
infants. We evaluated Determiner Chlamydia, which is an indirect enzyme
immunoassay, for an epidemiological study of vertical transmission of C.
trachomatis. Pregnant women were examined by Chlamydiazyme (Abott) using
endcervical swabs. Maternal and cord bloods were taken for detection of
IgG and IgA antibodies against C. trachomatis, by Determiner Chlamydia
(Chiba Serum Institute). Pregnant women were classified into 3 groups as
follows. Group 1 (n=10): Ag(+), IgG(+), IgA(+), Group 2 (n=8): Ag(+),
IgG(+), IgA(-), Group 3 (n=16): Ag(-), IgG(+), IgA(+). Babies from each
group were followed up for clinical symptoms, chlamydial antigens and
serum antibodies. Three infants from Group 1 and one from Group 2
mothers showed increased IgA by Determiner Chlamydia after 3 months of
age. All 4 infants had respiratory symptoms and chlamydial antigens were
detected from respiratory tract. None of cord bloods was positive for
IgA antibody. Determiner Chlamydia is easy to perform and is useful
method for diagnosis of respiratory infections during early infancy.
Significance of IgA antibody for C. trachomatis infection should be
studied further.
DE Antibodies, Bacterial/BLOOD Antigens, Bacterial/BLOOD *Chlamydia
trachomatis/IMMUNOLOGY Chlamydia
Infections/*CONGENITAL/DIAGNOSIS/IMMUNOLOGY Female Human IgA/BLOOD
IgG/BLOOD *Immunoenzyme Techniques Infant, Newborn
Pneumonia/CONGENITAL/DIAGNOSIS/IMMUNOLOGY Pregnancy Pregnancy
Complications, Infectious/*DIAGNOSIS/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).